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Article

An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis.

Rheumatology (Oxford, England) - 1 Jan 2016

Jiang Xia, Källberg Henrik, Chen Zuomei, Ärlestig Lisbeth, Rantapää-Dahlqvist Solbritt, Davila Sonia, Klareskog Lars, Padyukov Leonid, Alfredsson Lars

Abstract excerpt

OBJECTIVE: To investigate the gene-environment interaction between smoking and single nucleotide polymorphisms (SNPs), using Immunochip material, on the risk of developing either of two serologically defined subsets of RA. METHODS: Interaction between smoking and 133,648 genetic markers from the Immunochip was examined for two RA subsets, defined by the presence or absence of ACPA. A total of 1590 ACPA-positive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26272072
DOI: 10.1093/rheumatology/kev285

Genes

BTNL2
TAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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