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Article

Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis.

Annals of the rheumatic diseases - 1 Jan 2010

Karlson E W, Chang S-C, Cui J, Chibnik L B, Fraser P A, De Vivo I, Costenbader K H

Abstract excerpt

BACKGROUND: Previous studies have reported an interaction between ever cigarette smoking and the presence of the human leukocyte antigen (HLA)-DRB1 shared epitope (SE) genotype and rheumatoid arthritis (RA) risk. To address the effect of dosage, a case-control study nested within two prospective cohorts to determine the interaction between heavy smoking and the HLA-SE was conducted. METHODS: Blood was obtained...

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes

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Source

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Identifiers

PMID: 19151010
DOI: 10.1136/ard.2008.102962
PMCID: PMC2952498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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