Article
HLA-DRB1 Amino Acid Positions 11/13, 71, and 74 Are Associated With Inflammation Level, Disease Activity, and the Health Assessment Questionnaire Score in Patients With Inflammatory Polyarthritis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Nov 2016
Ling Stephanie F, Viatte Sebastien, Lunt Mark, Van Sijl Alper M, Silva-Fernandez Lucia, Symmons Deborah P M, Young Adam, Macgregor Alexander J, Barton Anne
Abstract excerpt
OBJECTIVE: Rheumatoid arthritis (RA) susceptibility HLA-DRB1 haplotypes based on amino acid positions 11/13, 71, and 74 predict radiographic damage. The mechanism of action is unknown, but it may be mediated by inflammation. We undertook this study to systematically investigate the effect of these amino acids on nonradiographic measures of disease activity/outcomes. METHODS: We tested the association of RA...
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