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Article

Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity.

American journal of human genetics - 3 Apr 2014

Han Buhm, Diogo Dorothée, Eyre Steve, Kallberg Henrik, Zhernakova Alexandra, Bowes John, Padyukov Leonid, Okada Yukinori, González-Gay Miguel A, Rantapää-Dahlqvist Solbritt, Martin Javier, Huizinga Tom W J, Plenge Robert M, Worthington Jane, Gregersen Peter K, Klareskog Lars, de Bakker Paul I W, Raychaudhuri Soumya

Abstract excerpt

Despite progress in defining human leukocyte antigen (HLA) alleles for anti-citrullinated-protein-autoantibody-positive (ACPA(+)) rheumatoid arthritis (RA), identifying HLA alleles for ACPA-negative (ACPA(-)) RA has been challenging because of clinical heterogeneity within clinical cohorts. We imputed 8,961 classical HLA alleles, amino acids, and SNPs from Immunochip data in a discovery set of 2,406 ACPA(-) RA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24656864
DOI: 10.1016/j.ajhg.2014.02.013
PMCID: PMC3980428

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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