Article
Genomic landscape of adenoid cystic carcinoma of the breast.
The Journal of pathology - 1 Oct 2015
Martelotto Luciano G, De Filippo Maria R, Ng Charlotte K Y, Natrajan Rachael, Fuhrmann Laetitia, Cyrta Joanna, Piscuoglio Salvatore, Wen Huei-Chi, Lim Raymond S, Shen Ronglai, Schultheis Anne M, Wen Y Hannah, Edelweiss Marcia, Mariani Odette, Stenman Göran, Chan Timothy A, Colombo Pierre-Emmanuel, Norton Larry, Vincent-Salomon Anne, Reis-Filho Jorge S, Weigelt Britta
Abstract excerpt
Adenoid cystic carcinoma (AdCC) is a rare type of triple-negative breast cancer (TNBC) characterized by the presence of the MYB-NFIB fusion gene. The molecular underpinning of breast AdCCs other than the MYB-NFIB fusion gene remains largely unexplored. Here we sought to define the repertoire of somatic genetic alterations of breast AdCCs. We performed whole-exome sequencing, followed by orthogonal validation, of...
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