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Article

Mutation profiling of adenoid cystic carcinomas from multiple anatomical sites identifies mutations in the RAS pathway, but no KIT mutations.

Histopathology - 1 Mar 2013

Wetterskog Daniel, Wilkerson Paul M, Rodrigues Daniel N, Lambros Maryou B, Fritchie Karen, Andersson Mattias K, Natrajan Rachael, Gauthier Arnaud, Di Palma Silvana, Shousha Sami, Gatalica Zoran, Töpfer Chantal, Vukovic Vesna, A'Hern Roger, Weigelt Britta, Vincent-Salomon Anne, Stenman Göran, Rubin Brian P, Reis-Filho Jorge S

Abstract excerpt

AIMS: The majority of adenoid cystic carcinomas (AdCCs), regardless of anatomical site, harbour the MYB-NFIB fusion gene. The aim of this study was to characterize the repertoire of somatic genetic events affecting known cancer genes in AdCCs. METHODS AND RESULTS: DNA was extracted from 13 microdissected breast AdCCs, and subjected to a mutation survey using the Sequenom OncoCarta Panel v1.0. Genes found to be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23398044
DOI: 10.1111/his.12050
PMCID: PMC4975515

Genes

KIT
BRAF
HRAS
MYB
NFIB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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