Article
Whole exome sequencing of adenoid cystic carcinoma.
The Journal of clinical investigation - 1 Jul 2013
Stephens Philip J, Davies Helen R, Mitani Yoshitsugu, Van Loo Peter, Shlien Adam, Tarpey Patrick S, Papaemmanuil Elli, Cheverton Angela, Bignell Graham R, Butler Adam P, Gamble John, Gamble Stephen, Hardy Claire, Hinton Jonathan, Jia Mingming, Jayakumar Alagu, Jones David, Latimer Calli, McLaren Stuart, McBride David J, Menzies Andrew, Mudie Laura, Maddison Mark, Raine Keiran, Nik-Zainal Serena, O'Meara Sarah, Teague Jon W, Varela Ignacio, Wedge David C, Whitmore Ian, Lippman Scott M, McDermott Ultan, Stratton Michael R, Campbell Peter J, El-Naggar Adel K, Futreal P Andrew
Abstract excerpt
Adenoid cystic carcinoma (ACC) is a rare malignancy that can occur in multiple organ sites and is primarily found in the salivary gland. While the identification of recurrent fusions of the MYB-NFIB genes have begun to shed light on the molecular underpinnings, little else is known about the molecular genetics of this frequently fatal cancer. We have undertaken exome sequencing in a series of 24 ACC to further...
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