Article
Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision-making.
Cold Spring Harbor molecular case studies - 1 Apr 2018
Chahal Manik, Pleasance Erin, Grewal Jasleen, Zhao Eric, Ng Tony, Chapman Erin, Jones Martin R, Shen Yaoqing, Mungall Karen L, Bonakdar Melika, Taylor Gregory A, Ma Yussanne, Mungall Andrew J, Moore Richard A, Lim Howard, Renouf Daniel, Yip Stephen, Jones Steven J M, Marra Marco A, Laskin Janessa
Abstract excerpt
Metastatic adenoid cystic carcinomas (ACCs) can cause significant morbidity and mortality. Because of their slow growth and relative rarity, there is limited evidence for systemic therapy regimens. Recently, molecular profiling studies have begun to reveal the genetic landscape of these poorly understood cancers, and new treatment possibilities are beginning to emerge. The objective is to use whole-genome and...
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