Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mutational landscape of adenoid cystic carcinoma.

Nature genetics - 1 Jul 2013

Ho Allen S, Kannan Kasthuri, Roy David M, Morris Luc G T, Ganly Ian, Katabi Nora, Ramaswami Deepa, Walsh Logan A, Eng Stephanie, Huse Jason T, Zhang Jianan, Dolgalev Igor, Huberman Kety, Heguy Adriana, Viale Agnes, Drobnjak Marija, Leversha Margaret A, Rice Christine E, Singh Bhuvanesh, Iyer N Gopalakrishna, Leemans C Rene, Bloemena Elisabeth, Ferris Robert L, Seethala Raja R, Gross Benjamin E, Liang Yupu, Sinha Rileen, Peng Luke, Raphael Benjamin J, Turcan Sevin, Gong Yongxing, Schultz Nikolaus, Kim Seungwon, Chiosea Simion, Shah Jatin P, Sander Chris, Lee William, Chan Timothy A

Abstract excerpt

Adenoid cystic carcinomas (ACCs) are among the most enigmatic of human malignancies. These aggressive salivary gland cancers frequently recur and metastasize despite definitive treatment, with no known effective chemotherapy regimen. Here we determined the ACC mutational landscape and report the exome or whole-genome sequences of 60 ACC tumor-normal pairs. These analyses identified a low exonic somatic mutation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Adenoid Cystic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Chlorocebus aethiops

Share to COS Cells

Share to Gene Expression Profiling

Share to Models, Biological

Share to Salivary Gland Neoplasms

Share to Tissue Array Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 23685749
DOI: 10.1038/ng.2643
PMCID: PMC3708595

Genes

MYB
CREBBP
KDM6A
NFIB
SMARCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mutational landscape of adenoid cystic carcinoma.PMID 23685749Read ↗

Whole exome sequencing of adenoid cystic carcinoma.Semantic proximity Read ↗

MYB-fusions and other potential actionable targets in adenoid cystic carcinoma.Semantic proximity Read ↗

Genomic landscape of adenoid cystic carcinoma of the breast.Semantic proximity Read ↗

Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision-making.Semantic proximity Read ↗

Whole-Genome Sequencing of Salivary Gland Adenoid Cystic CarcinomaSemantic proximity Read ↗

Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma.Semantic proximity Read ↗

Mutational landscape of primary pulmonary salivary gland-type tumors through targeted next-generation sequencing.Semantic proximity Read ↗

Adenoid cystic carcinoma: emerging role of translocations and gene fusionsSemantic proximity Read ↗

Comprehensive genomic profiling of relapsed and metastatic adenoid cystic carcinomas by next-generation sequencing reveals potential new routes to targeted therapies.Semantic proximity Read ↗

Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profilingSemantic proximity Read ↗

Transcriptomes define distinct subgroups of salivary gland adenoid cystic carcinoma with different driver mutations and outcomesSemantic proximity Read ↗

Molecular Profiling and the Impact of Treatment on Outcomes in Adenoid Cystic Carcinoma Type I and II.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.