Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma.

The Journal of clinical investigation - 1 Oct 2019

Ho Allen S, Ochoa Angelica, Jayakumaran Gowtham, Zehir Ahmet, Valero Mayor Cristina, Tepe Justin, Makarov Vladimir, Dalin Martin G, He Jie, Bailey Mark, Montesion Meagan, Ross Jeffrey S, Miller Vincent A, Chan Lindsay, Ganly Ian, Dogan Snjezana, Katabi Nora, Tsipouras Petros, Ha Patrick, Agrawal Nishant, Solit David B, Futreal P Andrew, El Naggar Adel K, Reis-Filho Jorge S, Weigelt Britta, Ho Alan L, Schultz Nikolaus, Chan Timothy A, Morris Luc Gt

Abstract excerpt

BACKGROUNDAdenoid cystic carcinoma (ACC) is a rare malignancy arising in salivary glands and other sites, characterized by high rates of relapse and distant spread. Recurrent/metastatic (R/M) ACCs are generally incurable, due to a lack of active systemic therapies. To improve outcomes, deeper understanding of genetic alterations and vulnerabilities in R/M tumors is needed.METHODSAn integrated genomic analysis of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Adenoid Cystic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Assembly and Disassembly

Share to Genes, myb

Share to Genomics

Share to Neoplasm Recurrence, Local

Share to Receptors, Notch

Share to Salivary Gland Neoplasms

Share to Telomerase

Source

Open in PubMed Open full text

Identifiers

PMID: 31483290
DOI: 10.1172/JCI128227
PMCID: PMC6763222

Genes

MYB
NOTCH1
ARID1B
KDM6A
KMT2C
MYBL1
NOTCH2
NOTCH3
NOTCH4
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma.PMID 31483290Read ↗

Transcriptomes define distinct subgroups of salivary gland adenoid cystic carcinoma with different driver mutations and outcomesSemantic proximity Read ↗

The mutational landscape of adenoid cystic carcinoma.Semantic proximity Read ↗

Metastatic Adenoid Cystic Carcinoma: Genomic Landscape and Emerging Treatments.Semantic proximity Read ↗

MYB-fusions and other potential actionable targets in adenoid cystic carcinoma.Semantic proximity Read ↗

Mutational landscape of primary pulmonary salivary gland-type tumors through targeted next-generation sequencing.Semantic proximity Read ↗

Adenoid cystic carcinoma: emerging role of translocations and gene fusionsSemantic proximity Read ↗

Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision-making.Semantic proximity Read ↗

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.Semantic proximity Read ↗

Whole-Genome Sequencing of Common Salivary Gland Carcinomas: Subtype-Restricted and Shared Genetic Alterations.Semantic proximity Read ↗

Spatio-Temporal Genomic Heterogeneity, Phylogeny, and Metastatic Evolution in Salivary Adenoid Cystic CarcinomaSemantic proximity Read ↗

Molecular Profiling and the Impact of Treatment on Outcomes in Adenoid Cystic Carcinoma Type I and II.Semantic proximity Read ↗

Single-cell RNA sequencing identifies a paracrine interaction that may drive oncogenic notch signaling in human adenoid cystic carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.