Article
MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB-NFIB fusion gene.
The Journal of pathology - 1 Feb 2018
Kim Jisun, Geyer Felipe C, Martelotto Luciano G, Ng Charlotte Ky, Lim Raymond S, Selenica Pier, Li Anqi, Pareja Fresia, Fusco Nicola, Edelweiss Marcia, Kumar Rahul, Gularte-Merida Rodrigo, Forbes Andre N, Khurana Ekta, Mariani Odette, Badve Sunil, Vincent-Salomon Anne, Norton Larry, Reis-Filho Jorge S, Weigelt Britta
Abstract excerpt
Breast adenoid cystic carcinoma (AdCC), a rare type of triple-negative breast cancer, has been shown to be driven by MYB pathway activation, most often underpinned by the MYB-NFIB fusion gene. Alternative genetic mechanisms, such as MYBL1 rearrangements, have been reported in MYB-NFIB-negative salivary gland AdCCs. Here we report on the molecular characterization by massively parallel sequencing of four breast...
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