Article
Molecular Profiling of Sinonasal Adenoid Cystic Carcinoma: Canonical and Noncanonical Gene Fusions and Mutation.
The American journal of surgical pathology - 1 Mar 2025
Skálová Alena, Bradová Martina, Agaimy Abbas, Laco Jan, Badual Cécile, Ihrler Stephan, Damjanov Ivan, Rupp Niels J, Bacchi Carlos E, Mueller Sarina, Ventelä Sami, Zhang Da, Comperat Eva, Martínek Petr, Šíma Radek, Vaněček Tomas, Grossmann Petr, Steiner Petr, Hájková Veronka, Kovářová Inka, Michal Michal, Leivo Ilmo
Abstract excerpt
Adenoid cystic carcinomas (AdCC) of salivary gland origin have long been categorized as fusion-defined carcinomas owing to the almost universal presence of the gene fusion MYB::NFIB , or less commonly MYBL1::NFIB. Sinonasal AdCC is an aggressive salivary gland malignancy with no effective systemic therapy. Therefore, it is urgent to search for potentially targetable genetic alterations associated with AdCC. We...
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