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Article

Molecular Profiling of Sinonasal Adenoid Cystic Carcinoma

6 Jan 2025

Abstract excerpt

Adenoid cystic carcinomas (AdCC) of salivary gland origin have long been categorized as fusion-defined carcinomas owing to the almost universal presence of the gene fusion MYB::NFIB , or less commonly MYBL1::NFIB. Sinonasal AdCC is an aggressive salivary gland malignancy with no effective systemic therapy. Therefore, it is urgent to search for potentially targetable genetic alterations associated with AdCC. We...

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PMID: 39760648
DOI: 10.1097/pas.0000000000002349

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