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Article

A Generalized Sequential Bonferroni Procedure for GWAS in Admixed Populations Incorporating Admixture Mapping Information into Association Tests.

Human heredity - 1 Jan 2015

Chen Wenan, Ren Chunfeng, Qin Huaizhen, Archer Kellie J, Ouyang Weiwei, Liu Nianjun, Chen Xiangning, Luo Xingguang, Zhu Xiaofeng, Sun Shumei, Gao Guimin

Abstract excerpt

OBJECTIVE: To develop effective methods for GWAS in admixed populations such as African Americans. METHODS: We show that, when testing the null hypothesis that the test SNP is not in background linkage disequilibrium with the causal variants, several existing methods cannot control well the family-wise error rate (FWER) in the strong sense in GWAS. These existing methods include association tests adjusting for...

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Identifiers

PMID: 26087776
DOI: 10.1159/000381474
PMCID: PMC4821476

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Source receipt: pubmed, retrieved 7 Sept 2026.

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