Article
A Generalized Sequential Bonferroni Procedure for GWAS in Admixed Populations Incorporating Admixture Mapping Information into Association Tests.
Human heredity - 1 Jan 2015
Chen Wenan, Ren Chunfeng, Qin Huaizhen, Archer Kellie J, Ouyang Weiwei, Liu Nianjun, Chen Xiangning, Luo Xingguang, Zhu Xiaofeng, Sun Shumei, Gao Guimin
Abstract excerpt
OBJECTIVE: To develop effective methods for GWAS in admixed populations such as African Americans. METHODS: We show that, when testing the null hypothesis that the test SNP is not in background linkage disequilibrium with the causal variants, several existing methods cannot control well the famil...
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