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Adjustment for local ancestry in genetic association analysis of admixed populations.

Bioinformatics (Oxford, England) - 1 Mar 2011

Wang Xuexia, Zhu Xiaofeng, Qin Huaizhen, Cooper Richard S, Ewens Warren J, Li Chun, Li Mingyao

Abstract excerpt

MOTIVATION: Admixed populations offer a unique opportunity for mapping diseases that have large disease allele frequency differences between ancestral populations. However, association analysis in such populations is challenging because population stratification may lead to association with loci unlinked to the disease locus. METHODS AND RESULTS: We show that local ancestry at a test single nucleotide...

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Computer Simulation
Gene Frequency
Genetic Predisposition to Disease
Genetics, Population
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Likelihood Functions

Logistic Models

Polymorphism, Single Nucleotide

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PMID: 21169375
DOI: 10.1093/bioinformatics/btq709
PMCID: PMC3042179

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