Article
Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events Among African Americans in 2 Large Cohort Studies.
Circulation. Cardiovascular genetics - 1 Apr 2017
Shendre Aditi, Wiener Howard, Irvin Marguerite R, Zhi Degui, Limdi Nita A, Overton Edgar T, Wassel Christina L, Divers Jasmin, Rotter Jerome I, Post Wendy S, Shrestha Sadeep
Abstract excerpt
BACKGROUND: Local ancestry may contribute to the disproportionate burden of subclinical and clinical cardiovascular disease among admixed African Americans compared with other populations, suggesting a rationale for admixture mapping. METHODS AND RESULTS: We estimated local European ancestry (LEA) using Local Ancestry inference in adMixed Populations using Linkage Disequilibrium method (LAMP-LD) and evaluated the...
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