Article
Genome-wide detection of natural selection in African Americans pre- and post-admixture.
Genome research - 1 Mar 2012
Jin Wenfei, Xu Shuhua, Wang Haifeng, Yu Yongguo, Shen Yiping, Wu Bailin, Jin Li
Abstract excerpt
It is particularly meaningful to investigate natural selection in African Americans (AfA) due to the high mortality their African ancestry has experienced in history. In this study, we examined 491,526 autosomal single nucleotide polymorphisms (SNPs) genotyped in 5210 individuals and conducted a genome-wide search for selection signals in 1890 AfA. Several genomic regions showing an excess of African or European...
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