Article
Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium.
PLoS genetics - 1 Apr 2011
Pasaniuc Bogdan, Zaitlen Noah, Lettre Guillaume, Chen Gary K, Tandon Arti, Kao W H Linda, Ruczinski Ingo, Fornage Myriam, Siscovick David S, Zhu Xiaofeng, Larkin Emma, Lange Leslie A, Cupples L Adrienne, Yang Qiong, Akylbekova Ermeg L, Musani Solomon K, Divers Jasmin, Mychaleckyj Joe, Li Mingyao, Papanicolaou George J, Millikan Robert C, Ambrosone Christine B, John Esther M, Bernstein Leslie, Zheng Wei, Hu Jennifer J, Ziegler Regina G, Nyante Sarah J, Bandera Elisa V, Ingles Sue A, Press Michael F, Chanock Stephen J, Deming Sandra L, Rodriguez-Gil Jorge L, Palmer Cameron D, Buxbaum Sarah, Ekunwe Lynette, Hirschhorn Joel N, Henderson Brian E, Myers Simon, Haiman Christopher A, Reich David, Patterson Nick, Wilson James G, Price Alkes L
Abstract excerpt
While genome-wide association studies (GWAS) have primarily examined populations of European ancestry, more recent studies often involve additional populations, including admixed populations such as African Americans and Latinos. In admixed populations, linkage disequilibrium (LD) exists both at a fine scale in ancestral populations and at a coarse scale (admixture-LD) due to chromosomal segments of distinct...
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