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Article

GWAS in the southern African context.

PloS one - 1 Jan 2022

Swart Yolandi, van Eeden Gerald, Uren Caitlin, van der Spuy Gian, Tromp Gerard, Möller Marlo

Abstract excerpt

Researchers would generally adjust for the possible confounding effect of population structure by considering global ancestry proportions or top principle components. Alternatively, researchers would conduct admixture mapping to increase the power to detect variants with an ancestry effect. This is sufficient in simple admixture scenarios, however, populations from southern Africa can be complex multi-way admixed...

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PMID: 36170230
DOI: 10.1371/journal.pone.0264657
PMCID: PMC9518849

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