Ancestry-specific association mapping in admixed populations

Abstract excerpt

During the last decade genome–wide association studies have proven to be a powerful approach to identifying disease-causing variants. However, for admixed populations, most current methods for association testing are based on the assumption that the effect of a genetic variant is the same regardless of its ancestry. This is a reasonable assumption for a causal variant, but may not hold for the genetic variants tha...

Topics

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• American Indian or Alaska Native
• Black People
• Gene Frequency
• Genetics, Population
• Genome-Wide Association Study
• Genotype
• Phenotype
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

ab336292-d226-5c8e-a727-e95d3fb8afb0

DOI

10.1101/014001