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Article

Properties of global- and local-ancestry adjustments in genetic association tests in admixed populations.

Genetic epidemiology - 1 Mar 2018

Martin Eden R, Tunc Ilker, Liu Zhi, Slifer Susan H, Beecham Ashley H, Beecham Gary W

Abstract excerpt

Population substructure can lead to confounding in tests for genetic association, and failure to adjust properly can result in spurious findings. Here we address this issue of confounding by considering the impact of global ancestry (average ancestry across the genome) and local ancestry (ancestry at a specific chromosomal location) on regression parameters and relative power in ancestry-adjusted and -unadjusted...

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Identifiers

PMID: 29288582
DOI: 10.1002/gepi.22103
PMCID: PMC5811405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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