Article
The role of local ancestry adjustment in association studies using admixed populations.
Genetic epidemiology - 1 Sept 2014
Zhang Jianqi, Stram Daniel O
Abstract excerpt
Association analysis using admixed populations imposes challenges and opportunities for disease mapping. By developing some explicit results for the variance of an allele of interest conditional on either local or global ancestry and by simulation of recently admixed genomes we evaluate power and false-positive rates under a variety of scenarios concerning linkage disequilibrium (LD) and the presence of...
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