Article

Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics

2023-04-10

Abstract excerpt

The heritability explained by local ancestry markers in an admixed population provides crucial insight into the genetic architecture of a complex disease or trait. Estimation of can be susceptible to biases due to population structure in ancestral populations. Here, we present a novel approach, Heritability estimation from Admixture Mapping Summary STAtistics (HAMSTA), which uses summary statistics from admixtur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2397282c-dd3c-53a5-8c57-bd79370b02e7
DOI: 10.1101/2023.04.10.536252

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statisticsDOI 10.1101/2023.04.10.536252Read

Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics.Semantic proximity Read

Interpreting SNP heritability in admixed populations.Semantic proximity Read

Leveraging population admixture to characterize the heritability of complex traits.Semantic proximity Read

Leveraging local ancestry and cross-ancestry genetic architecture to improve genetic prediction of complex traits in admixed populations.Semantic proximity Read

On Using Local Ancestry to Characterize the Genetic Architecture of Human Phenotypes: Genetic Regulation of Gene Expression in Multiethnic or Admixed Populations as a ModelSemantic proximity Read

Summix: A method for detecting and adjusting for population structure in genetic summary data.Semantic proximity Read

LoGicAl: Local ancestry and genotype calling uncertainty-aware ancestry-specific allele frequency estimation from admixed samplesSemantic proximity Read

Causal effects on complex traits are similar across segments of different continental ancestries within admixed individualsSemantic proximity Read

Estimating heritability and its enrichment in tissue-specific gene sets in admixed populationsSemantic proximity Read

Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations.Semantic proximity Read

Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals.Semantic proximity Read