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Article

Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity.

Science translational medicine - 17 Jun 2015

Fu Suneng, Yalcin Abdullah, Lee Grace Y, Li Ping, Fan Jason, Arruda Ana Paula, Pers Benedicte M, Yilmaz Mustafa, Eguchi Kosei, Hotamisligil Gökhan S

Abstract excerpt

The endoplasmic reticulum (ER) plays a critical role in protein, lipid, and glucose metabolism as well as cellular calcium signaling and homeostasis. Perturbation of ER function and chronic ER stress are associated with many pathologies ranging from diabetes and neurodegenerative diseases to cancer and inflammation. Although ER targeting shows therapeutic promise in preclinical models of obesity and other...

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Identifiers

PMID: 26084805
DOI: 10.1126/scitranslmed.aaa9134
PMCID: PMC5063051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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