Article
A screen for mutants requiring activation of the unfolded protein response for viability.
Methods in enzymology - 1 Jan 2011
Thibault Guillaume, Ng Davis T W
Abstract excerpt
The unfolded protein response (UPR) is an intracellular signal transduction pathway that monitors endoplasmic reticulum (ER) homeostasis. Activation of the UPR is required to alleviate the effects of ER stress. However, our understanding of what physiologically constitutes ER stress or disequilibrium is incomplete. The current view suggests that stress manifests as the functional capacity of the ER becomes...
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