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Article

Discovery of Modulators of Adipocyte Physiology Using Fully Functionalized Fragments.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Galmozzi Andrea, Parker Christopher G, Kok Bernard P, Cravatt Benjamin F, Saez Enrique

Abstract excerpt

Defects in adipocyte function associated with obesity drive the development of systemic insulin resistance and type 2 diabetes. Agents that correct obesity-linked adipocyte dysfunction serve as useful insulin sensitizers in humans, as is exemplified by the thiazolidinediones (TZDs). We have developed a new platform that integrates advanced chemoproteomics with phenotypic screening to identify small molecules that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29736714
DOI: 10.1007/978-1-4939-7847-2_9
PMCID: PMC6010189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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