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Discovery of a pyrazolopyridine alkaloid that mitigates neuronal ER stress and age-related decline

2025-07-18

Abstract excerpt

Endoplasmic reticulum (ER) stress contributes to the pathogenesis of neurodegenerative and age-associated diseases, motivating the search for compounds that enhance ER-stress resilience. Modulation of ER-redox pathways, including those associated with the oxidase ERO1A, can attenuate maladaptive unfolded protein response (UPR) signaling and improve cellular stress tolerance. Here we developed an integrative discov...

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Identifiers and source

Literature Corpus work
2a93f748-aa5c-5fee-a37b-97a65e01111e
DOI
10.1101/2025.07.14.664722
Open publication

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Discovery of a pyrazolopyridine alkaloid that mitigates neuronal ER stress and age-related declineDOI 10.1101/2025.07.14.664722
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