Article

ER Chaperone HYOU1 Couples MAM Remodeling to Autophagic Lipid Clearance in Atherosclerosis

2025-08-27

Abstract excerpt

<title>Abstract</title> <p>Endoplasmic reticulum (ER) stress and lipid accumulation are hallmarks of atherosclerosis, but their molecular crosstalk remains poorly defined. Here, we identify the ER chaperone HYOU1 as a critical regulator of mitochondria-associated membrane (MAM) remodeling and lipid homeostasis. HYOU1 is elevated in human and murine plaques and correlates with MAM-related gene networks. HYOU1 dele...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e7b34c18-c8d1-500f-bca4-49a9e2aaa031
DOI: 10.21203/rs.3.rs-7276074/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ER Chaperone HYOU1 Couples MAM Remodeling to Autophagic Lipid Clearance in AtherosclerosisDOI 10.21203/rs.3.rs-7276074/v1Read

Cryptotanshinone Targets HYOU1 to Rewire ER-Mitochondria Communication and Enhance Autophagy in AtherosclerosisSemantic proximity Read

Mechanistic Study of Yang-gan-jie-yu Granules in Treating Postmenopausal Metabolic-Associated Fatty Liver Disease Based on Transcriptomics and Network PharmacologySemantic proximity Read

ESR1-Activating Mutations Confer Metabolic Vulnerabilities in ER+ Breast Cancer.Semantic proximity Read

ALYREF inhibits ferroptosis in vascular endothelial cells and improves atherosclerosis by epigenetic modification of CISD1Semantic proximity Read

Lipid homeostasis is essential for a maximal ER stress responseSemantic proximity Read

<span class="word">Cholesterol <span class="word">in <span class="word"><span class="changedDisabled">Mitochondrial <span class="word"><span class="changedDisabled">Diseases – <span class="word"><span class="changedDisabled">Friend <span class="word">or <span class="word"><span class="changedDisabled">Foe?Semantic proximity Read

Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific SettingsSemantic proximity Read

Fatty acid metabolic interactome atlas linked to cellular longevitySemantic proximity Read

High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver diseaseSemantic proximity Read

Gualou Huoxue Jiedu Decoction inhibits VSMC phenotypic switching to alleviate atherosclerosis via promoting Mfap4 DNA methylation.Semantic proximity Read

Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites.Semantic proximity Read

Protective role of chaperone-mediated autophagy against atherosclerosisSemantic proximity Read