Article

A pipeline for natural small molecule inhibitors of endoplasmic reticulum stress

2022-02-20

Abstract excerpt

The homeostasis of eukaryotic cells is inseverable of that of the endoplasmic reticulum (ER). The main function of this organelle is the synthesis and folding of a significant portion of cellular proteins, while also being the major calcium reservoir of the cell. Upon unresolved ER stress, a set of stress response signaling pathways that are collectively labeled as the unfolded protein response (UPR) is activated....

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Literature Corpus work: d586068f-d067-562c-909e-e8f1a9437e74
DOI: 10.1101/2022.02.20.481203

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