Article

Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity

2025-04-05

Abstract excerpt

<h4>SUMMARY</h4> Pharmacological enhancement of endoplasmic reticulum (ER) proteostasis is an attractive strategy to mitigate pathology linked to etiologically-diverse protein misfolding diseases. However, despite this promise, few compounds have been identified that enhance ER proteostasis through defined mechanisms of action. We previously identified the phenylhydrazone-based compound AA263 as a compound that p...

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Literature Corpus work: 0f30db00-ca2b-5044-853c-52dc028802b5
DOI: 10.1101/2025.04.04.646800

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