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Article

Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors.

Journal of biomolecular screening - 1 Aug 2014

Pytel Dariusz, Seyb Kathleen, Liu Min, Ray Soumya S, Concannon John, Huang Mickey, Cuny Gregory D, Diehl J Alan, Glicksman Marcie A

Abstract excerpt

PERK is serine/threonine kinase localized to the endoplasmic reticulum (ER) membrane. PERK is activated and contributes to cell survival in response to a variety of physiological stresses that affect protein quality control in the ER, such as hypoxia, glucose depravation, increased lipid biosynthesis, and increased protein translation. Pro-survival functions of PERK are triggered by such stresses, suggesting that...

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Identifiers

PMID: 24598103
DOI: 10.1177/1087057114525853
PMCID: PMC4570879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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