Article
Quantitative high resolution melting: two methods to determine SNP allele frequencies from pooled samples.
BMC genetics - 13 Jun 2015
Capper Roxana L, Jin Young K, Lundgren Petra B, Peplow Lesa M, Matz Mikhail V, van Oppen Madeleine J H
Abstract excerpt
BACKGROUND: The advent of next-generation sequencing has brought about an explosion of single nucleotide polymorphism (SNP) data in non-model organisms; however, profiling these SNPs across multiple natural populations still requires substantial time and resources. RESULTS: Here, we introduce two cost-efficient quantitative High Resolution Melting (qHRM) methods for measuring allele frequencies at known SNP loci...
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