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Article

Accurate quantitation of allele-specific expression patterns by analysis of DNA melting.

Genome research - 1 Jul 2007

Jeong Sangkyun, Hahn Yoonsoo, Rong Qi, Pfeifer Karl

Abstract excerpt

Epigenetic and genetic mechanisms can result in large differences in expression levels of the two alleles in a diploid organism. Furthermore, these differences may be critical to phenotypic variations among individuals. In this study, we present a novel procedure and algorithm to precisely and accurately quantitate the relative expression of each allele. This method uses the differential melting properties of...

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PMID: 17545578
DOI: 10.1101/gr.6028507
PMCID: PMC1899120

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