Article
Clinical Implications of Rabphillin-3A-Like Gene Alterations in Breast Cancer.
PloS one - 1 Jan 2015
Putcha Balananda-Dhurjati Kumar, Jia Xu, Katkoori Venkat Rao, Salih Chura, Shanmugam Chandrakumar, Jadhav Trafina, Bovell Liselle C, Behring Michael P, Callens Tom, Messiaen Ludwine, Bae Sejong, Grizzle William E, Singh Karan P, Manne Upender
Abstract excerpt
For the rabphillin-3A-like (RPH3AL) gene, a putative tumor suppressor, the clinical significance of genetic alterations in breast cancers was evaluated. DNA and RNA were extracted from formalin-fixed, paraffin-embedded (FFPE) cancers and matching normal tissues. DNA samples were assessed for loss of heterozygosity (LOH) at the 17p13.3 locus of RPH3AL and the 17p13.1 locus of the tumor suppressor, TP53. RPH3AL was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.