Article
Correlation of allelic losses and clinicopathological factors in 504 primary breast cancers.
Breast cancer (Tokyo, Japan) - 1 Jan 2002
Nagahata Takemitsu, Hirano Akira, Utada Yoshihito, Tsuchiya Shinichi, Takahashi Kaoru, Tada Takashi, Makita Masujirou, Kasumi Fujio, Akiyama Futoshi, Sakamoto Goi, Nakamura Yusuke, Emi Mitsuru
Abstract excerpt
BACKGROUND: We have defined 18 chromosomal regions in which allelic losses were frequent among breast cancers. We examined whether specific allelic losses might correlate with any clinicopathological factors. METHODS: We tested DNA from matched normal and tumor tissues for loss of heterozygosity (LOH) at 18 microsatellite loci from a cohort of 504 patients who had undergone surgery for breast cancer. RESULTS: LOH...
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