Article
Evidence for a gene on 17p13.3, distal to TP53, as a target for allele loss in breast tumors without p53 mutations.
Cancer research - 1 Aug 1994
Cornelis R S, van Vliet M, Vos C B, Cleton-Jansen A M, van de Vijver M J, Peterse J L, Khan P M, Børresen A L, Cornelisse C J, Devilee P
Abstract excerpt
In breast cancer, loss of heterozygosity (LOH) on 17p is a frequent event and a likely target is the p53 gene on 17p13.1. However, several LOH mapping studies have indicated that, in some breast tumors, LOH affects only the most distal 17p markers, suggestive of a second tumor suppressor locus in...
Topics
- Alleles
- Base Sequence
- Breast Neoplasms
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- Codon
- DNA Mutational Analysis
- Exons
- Female
- Gene Deletion
- Genes, Tumor Suppressor
- Genes, p53
- Humans
- Molecular Sequence Data
- Point Mutation
- Tumor Suppressor Protein p53