Article
Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma.
Frontiers in bioscience : a journal and virtual library - 1 Jan 2008
Katkoori Venkat R, Jia Xu, Chatla Chakrapani, Kumar Sanjay, Ponnazhagan Selvarangan, Callens Tom, Messiaen Ludwine, Grizzle William E, Manne Upender
Abstract excerpt
The recently identified human ortholog of the Rabphillin-3A-Like (RPH3AL) gene, located at the 17p13.3 locus, has been assessed for its mutational status and clinical significance in colorectal adenocarcinoma (CRC). Prospectively collected 95 frozen CRCs and their matching benign colonic epithelial tissues were evaluated for mutations and mRNA expression. Since, we observed a higher incidence of a single...
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