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Article

Somatic TP53 mutations are relatively rare among adrenocortical cancers with the frequent 17p13 loss of heterozygosity.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2007

Libè Rossella, Groussin Lionel, Tissier Frédérique, Elie Caroline, René-Corail Fernande, Fratticci Amato, Jullian Eric, Beck-Peccoz Paolo, Bertagna Xavier, Gicquel Christine, Bertherat Jérôme

Abstract excerpt

PURPOSE: Allelic losses [loss of heterozygosity (LOH)] at the 17p13 locus are frequent (85%) in adrenocortical cancers. The tumor suppressor gene TP53 is located at 17p13. The aim of the study was to determine the frequency of TP53 somatic inactivating mutations in adrenocortical tumors with 17p13 LOH and their clinico-biological correlations. EXPERIMENTAL DESIGN: TP53 somatic mutations, intragenic LOH (VNTR1...

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Share to Adrenal Cortex Neoplasms
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PMID: 17289876
DOI: 10.1158/1078-0432.CCR-06-2085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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