Article
Trinucleotide repeat length variation in the human ribosomal protein L14 gene (RPL14): localization to 3p21.3 and loss of heterozygosity in lung and oral cancers.
Mutation research - 1 Nov 1998
Shriver S P, Shriver M D, Tirpak D L, Bloch L M, Hunt J D, Ferrell R E, Siegfried J M
Abstract excerpt
Chromosome 3p is consistently deleted in lung cancer, oral squamous cell carcinoma, and renal cell carcinoma, and is believed to contain several tumor suppressor genes. We have shown a role for chromosome 3 in tumor suppression by microcell-mediated chromosome transfer experiments. We have isolat...
Topics
- Biopsy
- Carcinoma, Renal Cell
- Carcinoma, Squamous Cell
- Chromosome Mapping
- Chromosomes, Human, Pair 3
- Cloning, Molecular
- Genetic Markers
- Genetic Variation
- Humans
- In Situ Hybridization, Fluorescence
- Karyotyping
- Loss of Heterozygosity
- Lung Neoplasms
