Article
High-resolution 19p13.2-13.3 allelotyping of breast carcinomas demonstrates frequent loss of heterozygosity.
Genes, chromosomes & cancer - 1 Nov 2004
Yang Tseng-Long, Su Yen-Rey, Huang Chiun-Sheng, Yu Jyh-Cherng, Lo Yen-Li, Wu Pei-Ei, Shen Chen-Yang
Abstract excerpt
In breast cancer, a high frequency of genomic deletion is found in chromosomal region 19p13. Of particular interest is that the LKB1 gene (also known as STK11) has been mapped to this region. LKB1 is responsible for Peutz-Jeghers syndrome (PJS), a genetic disease characterized by mucocutaneous pigmentation and gastrointestinal hematoma with an increased risk of developing cancer, including breast cancer. To...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Breast Neoplasms
- Chromosomes, Human, Pair 19
- Disease Progression
- Family Health
- Female
- Gene Deletion
- Genes, Tumor Suppressor
- Hematoma
- Humans
- Lasers
- Loss of Heterozygosity
- Microsatellite Repeats
- Middle Aged
- Polymerase Chain Reaction