Article
Human breast cancer: frequent p53 allele loss and protein overexpression.
Human genetics - 1 Feb 1993
Singh S, Simon M, Meybohm I, Jantke I, Jonat W, Maass H, Goedde H W
Abstract excerpt
A sample of 114 primary breast tumors and corresponding constitutional DNA were tested for loss of heterozygosity (LOH) of the YNZ22 and p53 genes, both located in the 17p13 region. Loss of the p53 allele was found in 28 of 44 primary breast carcinomas (64%). In contrast LOH in only 26 of 61 tumors (43%) was detected with the variable number of tandem repeats (VNTR) probe YNZ22 mapping at 17p13.3 close to the p53...
Topics
- Alleles
- Base Sequence
- Breast Neoplasms
- Chromosomes, Human, Pair 17
- DNA Probes
- Female
- Gene Deletion
- Genes, p53
- Heterozygote
- Humans
- Immunohistochemistry
- Molecular Sequence Data
- Neoplasm Proteins
- Nucleic Acid Hybridization
- Point Mutation
- Polymerase Chain Reaction
- Tumor Suppressor Protein p53