Loss of heterozygosity in normal tissue adjacent to breast carcinomas.

doi:10.1126/science.274.5295.2057

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Article

Loss of heterozygosity in normal tissue adjacent to breast carcinomas.

Science (New York, N.Y.) - 20 Dec 1996

Deng G, Lu Y, Zlotnikov G, Thor A D, Smith H S

Abstract excerpt

Loss of heterozygosity (LOH) was detected in morphologically normal lobules adjacent to breast cancers. The most frequent aberration was at chromosome 3p22-25; of ten cases with this LOH in the carcinoma, six displayed the same LOH in adjacent normal lobules. This suggests that in a subset of spo...

Topics

Alleles
Breast
Breast Neoplasms
Carcinoma, Ductal, Breast
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 3
DNA
DNA, Neoplasm
Female
Gene Deletion
Heterozygote
Humans
Polymerase Chain Reaction
Receptor, ErbB-2
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 8953032
DOI: 10.1126/science.274.5295.2057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8953032-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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