Article
Mutations of rabphillin-3A-like gene in colorectal cancers.
Oncology reports - 1 Jan 2000
Goi Takanori, Takeuchi Kazuo, Katayama Kanji, Hirose Kazuo, Yamaguchi Akio
Abstract excerpt
The chromosome region 17p shows frequently allele losses/mutations in colorectal cancers, and such frequent genetic alterations are a hallmark of the presence of tumor-suppressor gene. The RPH3AL, which is located at 17p13, has been identified from a candidate 17p13 medulloblastoma tumor suppressor locus. The aim of this study was to determine whether it is also altered in colorectal cancers. Mutational analyses...
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