Article
Loss of heterozygosity at 3p in benign lesions preceding invasive breast cancer.
The Journal of surgical research - 1 May 1999
Euhus D M, Maitra A, Wistuba I I, Alberts A, Albores-Saavedra J, Gazdar A F
Abstract excerpt
BACKGROUND: Loss of heterozygosity (LOH) at chromosome 3p is one of the most common genetic abnormalities identified in human cancers and has occasionally been noted in benign proliferative lesions predisposing to breast cancer. If the frequency of LOH at 3p in benign proliferative lesions correlates with the subsequent development of breast cancer, it may be possible to develop powerful tools for molecular risk...
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