Article

A better brain? Alternative spliced STIM2 in hominoids arises with synapse formation and creates a gain-of-function variant

2023-01-27

Abstract excerpt

Balanced Ca 2+ homeostasis is essential for cellular functions. STIM2 mediated Store-Operated Ca 2+ Entry (SOCE) regulates cytosolic and ER Ca 2+ concentrations, stabilizes dendritic spine formation and drives presynaptic spontaneous transmission and ER stress in neurons. Recently identified alternative spliced variants expand the STIM protein repertoire, uncover unique functions and facilitate our understandin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 716550ec-eefa-5c54-b345-a1e7f48ca4d4
DOI: 10.1101/2023.01.27.525873

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A better brain? Alternative spliced STIM2 in hominoids arises with synapse formation and creates a gain-of-function variantDOI 10.1101/2023.01.27.525873Read

A short isoform of STIM1 confers frequency-dependent synaptic enhancement.Semantic proximity Read

The Ca2+ Sensor STIM in Human Diseases.Semantic proximity Read

Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels.Semantic proximity Read

Orais and STIMs: physiological mechanisms and disease.Semantic proximity Read

A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and TranscriptionSemantic proximity Read

STIM1/ORAI1 Loss-of-Function and Gain-of-Function Mutations Inversely Impact on SOCE and Calcium Homeostasis and Cause Multi-Systemic Mirror DiseasesSemantic proximity Read

Conserved and species-specific STIM autoinhibition revealed by AlphaFold3-guided dissectionSemantic proximity Read

A homozygous STIM1 mutation impairs store-operated calcium entry and natural killer cell effector function without clinical immunodeficiencySemantic proximity Read

Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.Semantic proximity Read

Gain‐of‐Function Mutation in STIM1 (P.R304W) Is Associated with Stormorken SyndromeSemantic proximity Read

ORAI1 channel gating and selectivity is differentially altered by natural mutations in the first or third transmembrane domainSemantic proximity Read

A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy.Semantic proximity Read