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Article

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.

Nature communications - 1 Jan 2013

Stathopulos Peter B, Schindl Rainer, Fahrner Marc, Zheng Le, Gasmi-Seabrook Geneviève M, Muik Martin, Romanin Christoph, Ikura Mitsuhiko

Abstract excerpt

Orai1 calcium channels in the plasma membrane are activated by stromal interaction molecule-1 (STIM1), an endoplasmic reticulum calcium sensor, to mediate store-operated calcium entry (SOCE). The cytosolic region of STIM1 contains a long putative coiled-coil (CC)1 segment and shorter CC2 and CC3...

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Source

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Identifiers

PMID: 24351972
DOI: 10.1038/ncomms3963
PMCID: PMC3927877

Genes

STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24351972-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.PMID 24351972Read ↗

Interhelical interactions within the STIM1 CC1 domain modulate CRAC channel activation.Semantic proximity Read ↗

Molecular anatomy of the early events in STIM1 activation - oligomerization or conformational change?Semantic proximity Read ↗

Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.Semantic proximity Read ↗

Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1.Semantic proximity Read ↗

Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation.Semantic proximity Read ↗

Sequential activation of STIM1 links Ca2+ with luminal domain unfolding.Semantic proximity Read ↗

Activation of STIM1-Orai1 involves an intramolecular switching mechanism.Semantic proximity Read ↗

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate.Semantic proximity Read ↗

A single amino acid deletion in the ER Ca2+ sensor STIM1 reverses the in vitro and in vivo effects of the Stormorken syndrome-causing R304W mutation.Semantic proximity Read ↗

Review: Structure and Activation Mechanisms of CRAC Channels.Semantic proximity Read ↗

Intramolecular shielding maintains the ER Ca²⁺ sensor STIM1 in an inactive conformation.Semantic proximity Read ↗

Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding.Semantic proximity Read ↗

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