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STIM and ORAI proteins: crucial roles in hallmarks of cancer

21 Jan 2016

Abstract excerpt

Intracellular Ca(2+) signals play a central role in several cellular processes; therefore it is not surprising that altered Ca(2+) homeostasis regulatory mechanisms lead to a variety of severe pathologies, including cancer. Stromal interaction molecules (STIM) and ORAI proteins have been identified as critical components of Ca(2+) entry in both store-dependent (SOCE mechanism) and independent by intracellular...

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PMID: 26791491
DOI: 10.1152/ajpcell.00364.2015

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