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Article

STIM1, an essential and conserved component of store-operated Ca2 <b>+</b> channel function

2 May 2005

Abstract excerpt

Store-operated Ca2+ (SOC) channels regulate many cellular processes, but the underlying molecular components are not well defined. Using an RNA interference (RNAi)-based screen to identify genes that alter thapsigargin (TG)-dependent Ca2+ entry, we discovered a required and conserved role of Stim in SOC influx. RNAi-mediated knockdown of Stim in Drosophila S2 cells significantly reduced TG-dependent Ca2+ entry....

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Identifiers

PMID: 15866891
DOI: 10.1083/jcb.200502019

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

STIM1, an essential and conserved component of store-operated Ca2 <b>+</b> channel functionPMID 15866891Read ↗

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.Semantic proximity Read ↗

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels.Semantic proximity Read ↗

The Ca2+ Sensor STIM in Human Diseases.Semantic proximity Read ↗

Review: Structure and Activation Mechanisms of CRAC Channels.Semantic proximity Read ↗

Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1.Semantic proximity Read ↗

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.Semantic proximity Read ↗

Diseases caused by mutations in ORAI1 and STIM1.Semantic proximity Read ↗

A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.Semantic proximity Read ↗

Orai1 is an essential pore subunit of the CRAC channel.Semantic proximity Read ↗

Gated regulation of CRAC channel ion selectivity by STIM1.Semantic proximity Read ↗

Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity.Semantic proximity Read ↗

Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels.Semantic proximity Read ↗

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