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Article

A short isoform of STIM1 confers frequency-dependent synaptic enhancement.

Cell reports - 16 Mar 2021

Ramesh Girish, Jarzembowski Lukas, Schwarz Yvonne, Poth Vanessa, Konrad Maik, Knapp Mona L, Schwär Gertrud, Lauer Anna A, Grimm Marcus O W, Alansary Dalia, Bruns Dieter, Niemeyer Barbara A

Abstract excerpt

Store-operated Ca2+-entry (SOCE) regulates basal and receptor-triggered Ca2+ signaling with STIM proteins sensing the endoplasmic reticulum (ER) Ca2+ content and triggering Ca2+ entry by gating Orai channels. Although crucial for immune cells, STIM1's role in neuronal Ca2+ homeostasis is controversial. Here, we characterize a splice variant, STIM1B, which shows exclusive neuronal expression and protein content...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33730587
DOI: 10.1016/j.celrep.2021.108844

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