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Article

In vivo epigenetic reprogramming of primary human colon cancer cells enhances metastases.

Journal of molecular cell biology - 1 Apr 2016

Singovski Grigori, Bernal Carolina, Kuciak Monika, Siegl-Cachedenier Irene, Conod Arwen, Ruiz i Altaba Ariel

Abstract excerpt

How metastases develop is not well understood and no genetic mutations have been reported as specific metastatic drivers. Here we have addressed the idea that epigenetic reprogramming by GLI-regulated pluripotent stemness factors promotes metastases. Using primary human colon cancer cells engrafted in mice, we find that transient expression of OCT4, SOX2, KLF4 +/- cMYC establishes an enhanced pro-metastatic state...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26031752
DOI: 10.1093/jmcb/mjv034
PMCID: PMC4816146

Genes

NANOG
GLI2
AXIN2
KLF4
NANOGP8
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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