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Article

MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells.

PloS one - 1 Jan 2015

Ogawa Hisataka, Wu Xin, Kawamoto Koichi, Nishida Naohiro, Konno Masamitsu, Koseki Jun, Matsui Hidetoshi, Noguchi Kozou, Gotoh Noriko, Yamamoto Tsuyoshi, Miyata Kanjiro, Nishiyama Nobuhiro, Nagano Hiroaki, Yamamoto Hirofumi, Obika Satoshi, Kataoka Kazunori, Doki Yuichiro, Mori Masaki, Ishii Hideshi

Abstract excerpt

Although cancer is a genetic disease, epigenetic alterations are involved in its initiation and progression. Previous studies have shown that reprogramming of colon cancer cells using Oct3/4, Sox2, Klf4, and cMyc reduces cancer malignancy. Therefore, cancer reprogramming may be a useful treatment...

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Identifiers

PMID: 25970424
DOI: 10.1371/journal.pone.0127119
PMCID: PMC4430240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25970424-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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